On-Prem ConnectWise customers are not able to trigger tickets after updating their ConnectWise instance

NOTE: Please these apply very rarely and should NEVER be the first steps taken to fix an issue of On-Prem customers not being to trigger alerts after an upgrade.

There are few things that would cause it to create the issues you are seeing in Manage for the API callback service.
 
To address this issue please follow the below basic troubleshooting steps:
 
A. Navigate to System >> member >> API Callbacks.
 
Please update the correct URL for these callbacks or inactivate/remove the callbacks which are not in use.
 
B. Navigate to System >> setup table >> integrator login >>
 
Please update the correct URL in the respective fields or remove the invalid URL or remove the integrator which is not in use. Invalid URLs such as “http:” can be made valid as “https:”
 
C. The last step is to remove the used private message queues which are stuck in the message queue and perform an IIS reset on the Manage server.(IIS reset is preferred to do in your non-business hours)
 
Once the stuck queue is deleted then immediately IIS reset needs to be done.
 
Here is the documentation to perform the step C. I have attached the word doc with file name "Word_doc_steps"
 
Thanks,